Pharmacy Course Lessons

Pharmacy Course

Musculoskeletal And Joint Disorders

• Analgesics - A drugs that relieve pain.

Pain - An unpleasant sensation.

• Tissue damage 
• Anxiety
• Depression
• Emotion
• Sorrow

Analgesics

1. NSAIDS
2. OPIOIDS
3. NON NSAIDS AND NON OPIOIDS

NSAIDS - Non Steroidal Anti Inflammatory Drugs  

Inflammatory - the body responses to injury

• pain
• swelling
  
• heat
• redness
• lost of function affected areas

NSAIDS ACTIONS

• Have anti inflammatory effect.
• Have analgesic effect.
• Have antipyretic effect.
• Have anti platelet effect
• Reduce the production of prostaglandin by inhibiting the enzyme * Cyclo-oxygenase, *cox-inhibitors.

Drugs

Non Selective Cox-inhibitors

•  Fenamic acid derivatives

mefenamic acid

• Propionic acid derivatives

Ibuprofen

Ketoprofen

Naproxin

Fenbufen

• Oxicms

Piroxicans

Meloxicam

Lornoxiacm

Tenoxicam

• Actic acid derivatives

Diclofanac

Acelofenac

Indometacin

Acemetacin

• Salacylic acid derivatives

Asprin

Diflumicacid

• Other

Nabumation

Niflumicacid

• Compound

Benorilate

Selective Cox-inhibitors

Celecoxib

parecoxib

Itoricoxib

Indication 

• Mild to moderate pain
• Pain and inflammation
• Musculoskeletal pain
• pyrexia
• Gout
• Antiplatelet effect
• Dysmenorrhoea
• Oseo arthritis
• Rheumatoid arthritis
• Post Operative pain

Caution

• Pregnancy (PR).
• Breast feeding (BF).
• Renal impairment.
• Coagulation defect - liquid change to jelly like mass .

Contraindication

• Allergic disorders - Reaction presence of a foreign substance.
•  Hyper sensitivity - Abnormal responses of foreign substance.
• Severe heart failure (HF) - Pumping action of the heart is integrate. 
• Ischemic heart disease (HID) 
•